We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Night cramps resolved
64 people found this helpful
Magnesium citrate effectively relieved my night cramps and joint pain. It has worked wonders, and I highly recommend it for those suffering from similar issues.
Read More
9
Effective with normalisation
54 people found this helpful
My husband and I have consumed three bottles of magnesium citrate, and I now feel its positive effects; I wake up without soreness, and my blood pressure remains stable. This easily absorbed magnesium type excels in activating D3 in the kidneys and promotes effective muscle and bone maintenance, making it vital for overall energy production and metabolism.
Read More
9
Knee pain alleviation
25 people found this helpful
I can't do without magnesium! My left knee pain, which hindered me from going down stairs, has improved vastly. After various products, it was the addition of magnesium that completed my treatment, returning my knee to normal.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 107 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
Night cramps resolved
64 people found this helpful
Magnesium citrate effectively relieved my night cramps and joint pain. It has worked wonders, and I highly recommend it for those suffering from similar issues.
Read More
9
Effective with normalisation
54 people found this helpful
My husband and I have consumed three bottles of magnesium citrate, and I now feel its positive effects; I wake up without soreness, and my blood pressure remains stable. This easily absorbed magnesium type excels in activating D3 in the kidneys and promotes effective muscle and bone maintenance, making it vital for overall energy production and metabolism.
Read More
9
Knee pain alleviation
25 people found this helpful
I can't do without magnesium! My left knee pain, which hindered me from going down stairs, has improved vastly. After various products, it was the addition of magnesium that completed my treatment, returning my knee to normal.
Read More
9
Restorative effects
24 people found this helpful
Since adding magnesium citrate to my routine, I have noticed significant improvements in muscle relaxation and stress reduction. It’s crucial for bone health and supports vital functions in the body. The increase in magnesium levels typically shows within six weeks, but I felt a change by the end of the first week, becoming calmer and more relaxed.
Read More
9
Essential for energy
24 people found this helpful
Magnesium is vital for ATP formation, affecting energy metabolism and the coordination of movements. It helps reduce joint pain, regulates muscle tone, and is crucial for vitamin absorption, among many other benefits.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, the time it takes to see results from magnesium citrate for bone pain and related issues can vary. Some users report experiencing noticeable improvements within the first week of taking the supplement. For example, one reviewer mentioned feeling significant changes, such as diminished joint and muscle pain, just after a week of use Read Review. Another user highlighted that they felt a change by the end of the first week, indicating improved relaxation and muscle relief Read Review.
On the other hand, some users suggest that while initial effects can be felt relatively quickly, optimal results in terms of overall health and pain relief may become more apparent after four to six weeks of consistent use Read Review. Therefore, if you’re taking magnesium for bone pain, you might expect to see some benefits within a week, but full effects could take longer to manifest.
This supplement appears to have some scientific backing for its use in managing bone pain, particularly magnesium-based treatments. Research indicates that magnesium can be beneficial for bone formation and pain relief associated with osteoporosis. One study developed a novel drug delivery system that combines magnesium with denosumab, which showed potential in encouraging cell growth and drug release for pain relief linked to osteoporosis, although further real-world studies are needed to confirm its effectiveness ([1]).
Additionally, there is evidence suggesting that choline magnesium trisalicylate (CMT) might help reduce bone pain in patients with metastatic cancer, where significant pain relief was observed shortly after treatment, even though the findings weren't uniformly statistically significant across all comparisons. This indicates that magnesium could play a role in alleviating bone pain, possibly in conjunction with traditional opioid treatments ([3]). Overall, while there are positive indications from the research, more extensive studies are warranted to fully evaluate and confirm the effectiveness of these magnesium-based interventions for bone pain.
Users have reported a range of improvements in their symptoms after using magnesium citrate, particularly for conditions involving muscle and joint pain. One reviewer indicated that magnesium citrate relieved their night cramps and joint pain, describing it as "wonders" and a product they highly recommend for those experiencing similar issues Read Review. Another user noted a significant reduction in their knee pain, which had previously hindered their mobility, attributing the improvement directly to magnesium Read Review. Additionally, several users have mentioned experiencing better sleep quality, reduced muscle tension, and significant relief from menstrual pain and other discomforts, emphasizing the importance of magnesium in their daily health routines Read Review.
While anecdotal experiences vary, many users felt improvements within the first few weeks of use, with some noting almost immediate relief from symptoms like leg and calf cramps Read Review. There are also success stories regarding magnesium's impact on sleep issues and energy levels, with users pleased to find their muscle and joint pains alleviated effectively Read Review. Overall, while results may differ from person to person, a majority of reviewers seem to have enjoyed tangible benefits from incorporating magnesium citrate into their health routines.
Users have reported varying experiences when combining magnesium citrate with other supplements for managing bone pain. One reviewer highlighted the benefits of pairing magnesium with vitamin K2, D3, and calcium, noting that this combination effectively alleviated joint pain and strengthened bones in her mother, who also experienced leg discomfort Read Review. Similarly, another user mentioned enhancing their magnesium regimen with additional magnesium forms and baths, which led to significant improvements in headaches, menstrual pain, and overall health Read Review.
Additionally, there are anecdotal reports of magnesium's synergistic effects when taken alongside ginkgo biloba. One user described a method of alleviating migraines by taking magnesium and ginkgo together, emphasizing the improved muscle relaxation and nervous system calming this combination provided Read Review. Overall, users seem to view combining magnesium with complementary supplements as a strategy to enhance pain relief and overall bodily function.
The optimal dose of magnesium for treating bone pain isn't explicitly defined in the available research, which emphasizes the complexity of dosage in different contexts. However, one study on choline magnesium trisalicylate (CMT), which contains magnesium, indicated a significant reduction in bone pain only one hour post-treatment in metastatic cancer patients [3]. This suggests that magnesium might provide rapid relief, but the exact dosages used in the study weren't specified.
Furthermore, another study highlighted the potential of magnesium in a drug delivery system aimed at osteoporosis, indicating that while magnesium ions can be beneficial for bone formation, more research is necessary to establish effective dosing for pain relief [1]. Without established guidelines or specific dosages from the studies, it’s essential to approach magnesium treatment cautiously and discuss any supplementation with a healthcare provider.
7.5
Improved joint pain
11 people found this helpful
Magnesium citrate has been beneficial for my husband. After giving it to him on a doctor's advice to aid sleep, I noticed significant changes after a week. His joint and muscle pain diminished, and he began to sleep more soundly. He takes one capsule three times daily. Although the capsules are large, they are easy to swallow. This supplement proves to be a valuable health aid.
9
Restorative effects
24 people found this helpful
Since adding magnesium citrate to my routine, I have noticed significant improvements in muscle relaxation and stress reduction. It’s crucial for bone health and supports vital functions in the body. The increase in magnesium levels typically shows within six weeks, but I felt a change by the end of the first week, becoming calmer and more relaxed.
9
Night cramps resolved
64 people found this helpful
Magnesium citrate effectively relieved my night cramps and joint pain. It has worked wonders, and I highly recommend it for those suffering from similar issues.
9
Knee pain alleviation
25 people found this helpful
I can't do without magnesium! My left knee pain, which hindered me from going down stairs, has improved vastly. After various products, it was the addition of magnesium that completed my treatment, returning my knee to normal.
9
Pain-free periods
7 people found this helpful
Menstrual pain has vanished! Initially, I avoided medication, but during severe cramps, I found it triggered hyperventilation. After starting magnesium, I was astonished that I experienced no pain. When I missed a dose, I noticed dull pain return, underscoring magnesium's importance! Additionally, my prolonged bleeding has stopped in just 3.4 days.
9
Pain relief fast
1 people found this helpful
My legs no longer ache! I had cramps and foot pain, and after taking magnesium, my feet stopped hurting within an hour. I was astonished at how quickly it worked, discovering that my leg cramps were related to magnesium deficiency.
9
Essential for wellbeing
9 people found this helpful
Excellent! Magnesium is a vital element in our bodies. It mitigates headaches, combats fatigue, stress, and insomnia, promotes muscle relaxation, and aids in overcoming depression swiftly. It also supports the musculoskeletal system, ensuring healthy bones and teeth. I take it regularly with meals, and the results are impressive! Moreover, for those dealing with constipation, magnesium is quite effective (taking 2-3 can remedy it). Highly recommended!
7.5
Relieves leg pain
1 people found this helpful
I ordered this for my mother, who was experiencing poor sleep, anxiety, and leg pain. This supplement alleviated her pain while walking, easing her joint aches. It combines vitamin K2, D3, and calcium to strengthen bones and relieve tension. While it slightly weakens my mother, at 55, I don't find it weakens me at 30. The packaging is large, but it's worth it.
9
Deficiency remedy noted
1 people found this helpful
I began taking magnesium at 33, feeling generally unwell with headaches and menstrual pain, plus night-time leg cramps. Initially, my husband dismissed it as muscle contractions. It was only when a doctor identified a magnesium deficiency that I started taking this. I found a 400 dosage insufficient, so I combined it with donat magnesium and baths, which ultimately improved my condition. Headaches and period pains have vanished, and I no longer experience swelling or cramps.
9
Migraine alleviation
1 people found this helpful
This miraculous magnesium saves me from migraines! I avoid taking pain relievers for headaches; instead, at the first sign of pain, I take two capsules of magnesium and two of ginkgo biloba. The magnesium helps relax my muscles and nervous system, while ginkgo enhances cerebral circulation. Interestingly, magnesium citrate can have a loosening effect on the bowels, but for me, it’s just beneficial. I hope sharing this will help others too!
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.